Table 1 Top 10 FDA-approved drugs identified using connectivity mapping
From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
| Ranking | GSE21032 | TCGA | ||||
|---|---|---|---|---|---|---|
| Drug | Cell line | Z-score¶ | Drug | Cell line | Z-score¶ | |
| 1 | MENADIONE | HEPG2 | – 15.8 | CLADRIBINE | A375 | – 17.5 |
| 2 | MENADIONE | A375 | – 14.0 | MENADIONE | A375 | – 15.6 |
| 3 | GEMCITABINE | A375 | – 13.1 | HOMOHARRINGTONINE | PC3 | – 15.0 |
| 4 | NICLOSAMIDE | HEPG2 | – 13.0 | MENADIONE | HEPG2 | – 14.6 |
| 5 | GEMCITABINE | HCC515 | – 12.1 | NICLOSAMIDE | HEPG2 | – 14.6 |
| 6 | CLADRIBINE | A375 | – 11.7 | DIGITOXIN | A549 | – 14.3 |
| 7 | DIGITOXIN | A549 | – 11.4 | AZACITIDINE | A375 | – 14.0 |
| 8 | DIGOXIN | PC3 | – 11.3 | CLOFARABINE | A375 | – 13.9 |
| 9 | PENTAMIDINE | HEPG2 | – 11.1 | GEMCITABINE | HCC515 | – 13.5 |
| 10 | TENIPOSIDE | A375 | – 11.1 | CLADRIBINE | PC3 | – 13.3 |