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Investigation strategy
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Cost (£) mean (95% CI)
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Incremental Cost (£) mean (95% CI)
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QALY mean (95% CI)
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Incremental effect mean (95% CI)
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ICER (£)
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Probability of each treatment strategy is cost-effective for different threshold values for society’s willingness to pay
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£0 k (%)
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£10 k (%)
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£20 k (%)
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£30 k (%)
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£50 k (%)
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Base case, 24 months post randomisation
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Urethroplasty (n = 46)
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4869 (4123, 5614)
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2148 (689, 3606)
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1.74 (1.61, 1.86)
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− 0.01 (− 0.17, 0.14)
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0
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0
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1
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3
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13
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Urethrotomy (n = 46)
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2721 (1444, 3999)
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1.75 (1.65, 1.85)
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Dominant
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100
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100
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99
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97
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87
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24 months post randomisation (rescaled QALY)
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Urethroplasty (n = 46)
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4869 (4123, 5614)
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2148 (689, 3606)
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1.65 (1.55, 1.76)
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− 0.04 (− 0.18, 0.11)
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0
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0
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0
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1
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4
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Urethrotomy (n = 46)
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2721 (1444, 3999)
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1.69 (1.59, 1.79)
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Dominant
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100
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100
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100
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99
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96
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24 months post surgery
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Urethroplasty (n = 37)
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4963 (3977, 5949)
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1672 (− 65, 3409)
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1.73 (1.54, 1.92)
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− 0.04 (− 0.24, 0.16)
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0
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0
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4
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9
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15
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Urethrotomy (n = 48)
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3291 (1947, 4636)
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1.77 (1.67, 1.87)
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Dominant
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100
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100
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96
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91
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85
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24 months post surgery (rescaled QALY)
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Urethroplasty (n = 37)
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4963 (3977, 5949)
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1672 (− 65, 3409)
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1.42 (1.28, 1.56)
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− 0.16 (− 0.31, − 0.01)
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0
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0
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0
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0
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0
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Urethrotomy (n = 48)
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3291 (1947, 4636)
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1.58 (1.49, 1.67)
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Dominant
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100
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100
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100
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100
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100
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24 months post randomisation with imputation
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Urethroplasty (n = 108)
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4704 (4102, 5305)
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1333 (410, 2256)
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1.73 (1.67, 1.79)
| − 0⋅03 (− 0.11, 0.05) | |
0
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0
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0
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0
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1
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Urethrotomy (n = 112)
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3371 (2667, 4074)
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1.76 (1.71, 1.81)
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Dominant
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100
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100
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100
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100
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99
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24 months post randomisation with imputation (rescaled QALY)
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Urethroplasty (n = 108)
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4704 (4102, 5305)
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1333 (410, 2256)
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1.67 (1.62, 1.73)
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− 0.05 (− 0.13, 0.02)
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0
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0
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0
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0
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0
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Urethrotomy (n = 112)
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3371 (2667, 4074)
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1.72 (1.67, 1.77)
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Dominant
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100
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100
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100
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100
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100
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24 months post surgery with imputation
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Urethroplasty (n = 108)
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4704 (4102, 5305)
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1333 (410, 2256)
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1.75 (1.68, 1.82)
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− 0.02 (− 0.10, 0.07)
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0
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0
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0
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0
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3
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Urethrotomy (n = 112)
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3371 (2667, 4074)
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1.76 (1.71, 1.82)
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Dominant
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100
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100
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100
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100
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97
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24 months post surgery with imputation (rescaled QALY)
| | | | | | | | | | |
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Urethroplasty (n = 108)
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4704 (4102, 5305)
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1333 (410, 2256)
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1.67 (1.61, 1.73)
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− 0.05 (− 0.12, 0.02)
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0
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0
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0
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0
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0
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Urethrotomy (n = 112)
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3371 (2667, 4074)
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1.72 (1.67, 1.77)
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Dominant
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100
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100
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100
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100
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100
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