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|
Variable
|
Overall survival
|
Progression-free survival
|
|---|
|
HR
|
95 %CL
|
P
|
HR
|
95 %CL
|
P
|
|---|
|
Model 1
|
|
Age1,2
|
/
|
/
|
NS
|
/
|
/
|
NS
|
|
Symptom at presentation1,2
|
/
|
/
|
NS
|
/
|
/
|
NS
|
|
Histologic subtype1,2
|
|
CCRCC
|
Ref
| | |
Ref
| | |
|
Non-CCRCC
|
/
|
/
|
NS
|
2.835
|
1.403–5.728
|
0.004
|
|
Nuclear grade1,2
|
|
I–II
|
Ref
| | |
Ref
| | |
|
III–IV
|
/
|
/
|
NS
|
2.069
|
1.059–4.039
|
0.033
|
|
Lymph node metastasis1,2
|
4.811
|
1.365–16.961
|
0.015
|
5.739
|
2.136–15.420
|
0.001
|
|
Necrosis2
|
/
|
/
|
/
|
/
|
/
|
NS
|
|
Blood parameters
|
|
PLR2
|
/
|
/
|
/
|
/
|
/
|
NS
|
|
Thrombocytosis1,2
|
/
|
/
|
NS
|
2.324
|
1.215–4.446
|
0.011
|
|
Anaemia1,2
|
2.873
|
1.310–6.299
|
0.008
|
/
|
/
|
NS
|
|
Model 2
|
|
SSIGN score
|
|
Low-risk (score 2–4)
|
Ref
| | |
Ref
| | |
|
Intermediate-risk (score 5–7)
|
1.447
|
0.499–4.193
|
0.496
|
1.833
|
0.871–3.858
|
0.111
|
|
High-risk (score 8–11)
|
5.847
|
1.838–18.603
|
0.003
|
3.025
|
1.230–7.436
|
0.016
|
|
Blood parameters
|
|
PLR2
|
/
|
/
|
/
|
/
|
/
|
NS
|
|
Thrombocytosis1,2
|
/
|
/
|
NS
|
2.375
|
1.245–4.469
|
0.008
|
|
Anaemia1,2
|
3.453
|
1.495–7.978
|
0.004
|
/
|
/
|
NS
|
- NS not statistically significant
-
1The variable that was selected into the multivariate model correlated with overall survival
-
2The variable that was selected into the multivariate model correlated with progression-free survival
