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Table 3 Univariate Cox regression analysis of prognostic factors correlated with overall survival and progression-free survival

From: Preoperative anaemia and thrombocytosis predict adverse prognosis in non‐metastatic renal cell carcinoma with tumour thrombus

Variable Overall survival Progression-free survival
HR 95 %CL P-value HR 95 %CL P-value
Age* 0.980 0.943–1.018 0.289 0.976 0.950–1.003 0.086
Sex (male vs. female)       
Male Ref    Ref   
Female 0.874 0.330–2.315 0.787 0.801 0.390–1.645 0.545
ASA score       
I + II Ref    Ref   
III 1.511 0.518–4.412 0.450 1.110 0.471–2.613 0.812
Symptom at presentation 1.858 0.745–4.629 0.184 1.878 0.978–3.603 0.058
Histologic subtype       
CCRCC Ref    Ref   
Non-CCRCC 2.279 0.909–5.716 0.079 3.007 1.620–5.845 0.001
Tumour thrombus level       
0–II Ref    Ref   
III–IV 1.259 0.525–3.022 0.606 1.149 0.609–2.167 0.669
Tumour size* 1.032 0.910–1.170 0.626 1.015 0.926–1.113 0.749
Invasion of venous wall 1.455 0.681–3.112 0.333 1.450 0.824–2.551 0.198
Nuclear grade       
I–II Ref    Ref   
III–IV 2.283 0.955–5.456 0.063 2.368 1.255–4.468 0.008
Lymph node metastasis 5.622 1.872–16.888 0.002 3.871 1.504–9.962 0.005
Necrosis 1.889 0.850–4.198 0.119 1.709 0.946–3.028 0.066
SSIGN score       
Low-risk (score 2–4) Ref    Ref   
Intermediate-risk (score 5–7) 2.158 0.771–6.039 0.143 2.311 1.125–4.749 0.023
High-risk (score 8–11) 5.653 1.808–17.677 0.003 3.799 1.598–9.033 0.003
Blood parameters       
NLR* 1.090 0.959–1.239 0.189 1.019 0.905–1.148 0.750
PLR* 1.001 0.998–1.004 0.377 1.002 1.000–1.004 0.084
AST/ALT* 1.117 0.553–2.256 0.758 1.212 0.983–1.765 0.238
Thrombocytosis 2.288 0.946–5.532 0.066 3.307 1.819–6.009 < 0.001
Anaemia 2.991 1.384–6.467 0.005 2.065 1.196–3.566 0.009
ALB* 0.959 0.902–1.021 0.191 0.979 0.935–1.026 0.384
SCR* 1.003 0.987–1.019 0.714 0.994 0.981–1.007 0.376
SCa* 0.666 0.064–6.885 0.733 3.740 0.769–18.205 0.102
ALP* 1.006 0.998–1.013 0.150 1.001 0.995–1.008 0.638
  1. *As continuous variable
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