Table 2 Characteristics of studies and the schedule of drug administration among the included studies
| Study | Cases | Sex(M/F) | Age (year) | Type of patients | Stage | Grade | Comparison | Dosage of intervention | Follow-up |
|---|---|---|---|---|---|---|---|---|---|
| Dong 2017 [16] | 28 | NA | NA | NMIBC | NA | NA | GEM | 1000 mg weekly for 8 weeks followed by monthly instillations | 12 months |
| MMC | 20 mg weekly for 8 weeks followed by monthly instillations | ||||||||
| Lin 2016 [17] | 84 | 56/28 |
GEM:61 ± 4.2 MMC:62 ± 3.5 | NMIBC |
Tis: 3 Ta: 24 T1: 59 |
G1: 40 G2: 27 G3: 17 | GEM | 1000 mg weekly for 8 weeks followed by monthly instillations (a total of 1 year or 2 years) | 24 months |
| MMC | 30 mg weekly for 8 weeks followed by monthly instillations (a total of 1 year or 2 years) | ||||||||
| Sun 2016 [18] | 58 | 45/13 |
GEM: 37 ~ 83 MMC: 31 ~ 81 | NMIBC | NA | NA | GEM | 1000 mg weekly for 8 weeks followed by 10 monthly instillations (a total of 1 year) | 2 years |
| MMC | 20 mg weekly for 8 weeks followed by 10 monthly instillations (a total of 1 year) | ||||||||
| Xiaohong 2015 [19] | 56 | 45/11 |
GEM:51.26 ± 13.42 MMC:51.64 ± 12.39 | NMIBC |
Tis: 1 Ta: 10 T1: 45 |
G1: 13 G2: 41 G3: 2 | GEM | 1000 mg weekly for 8 weeks followed by 10 monthly instillations (a total of 1 year) | 1 year |
| MMC | 40 mg weekly for 8 weeks followed by 10 monthly instillations (a total of 1 year) | ||||||||
| Raffaele 2010 [20] | 109 | 93/16 |
GEM: 64.9 ± 10.5 MMC: 67.9 ± 10.2 | NMIBC |
Ta: 72 T1: 37 |
G1: 25 G2: 55 G3: 29 | GEM | 2000 mg weekly for 6 weeks followed by 10 monthly infusion during the first year | 36 months |
| MMC | 40 mg weekly for 4 weeks followed by 10 monthly infusion during the first year |